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Wednesday, September 18, 2019News

AD-RESYL by Silab: an active ingredient for the resilience of atopic skin

AD-RESYL de Silab : un actif pour la résilience des peaux atopiques

Silab Softcare research teams have demonstrated the clinical efficacy of fructosans from Ophiopogon japonicus in the reduction of flares of atopic dermatitis in Caucasian patients. This clinical study has just been published in the journal Acta Dermato-Venereologica, following a peer-review process by experts in the field.

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Despite their known adverse effects, corticosteroids are commonly used in the treatment of atopic dermatitis. With this in mind, Silab initiated research work with the aim of offering an alternative natural solution (AD-RESYL®). The company therefore extracted specific molecules (fructosans) from a plant emblematic of traditional Chinese medicine (Ophiopogon japonicus) and demonstrated their ability to prolong the period of remission between two flares.

The clinical efficacy of these natural molecules added to Diprobase® was evaluated in partnership with ClinReal Online (Toulouse), a CRO (Contract research organization) specializing in the field of clinical tests for dermatology. For this, a randomized, double-blind, placebocontrolled trial was conducted on a cohort of 104 Caucasian children and 144 Caucasian adults with slight to moderate atopic dermatitis.

The results obtained for both cohorts under dermatological supervision showed that these fructosans led to a reduction in the SCORAD (Scoring atopic dermatitis: atopic dermatitis severity score for monitoring of its progress) and an improvement in the quality of life of the patients and their families. Moreover, the significant reduction in relapse rate validated the benefit of topical care containing these natural molecules to maintain the remission phase as a relay of a corticosteroid treatment.

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