CosmeticOBS - L'Observatoire des cosmétiques
July 2, 2019SCCS

Hydroxypropyl p-Phenylenediamine (A165): Opinion of the SCCS pro Add to my portfolio
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Hydroxypropyl p-Phenylenediamine (A165): Opinion of the SCCS

The SCCS has just published its Opinion on the safety of two hair dye ingredients, Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165). This Opinion has been adopted during the plenary meeting of 20-21 June 2019, and is opened to comments until 9 September 2019.

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Background

The ingredients Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165) are intended to be used in oxidative hair colouring products up to a maximum on-head concentration of 2%.

For an exhaustive background information, see the article
Hydroxypropyl p-phenylenediamine and its dihydrochloride salt: Request for Opinion to SCCS, CosmeticOBS, 7 November 2017

Opinion

1. In light of the data provided, does the SCCS consider Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165), safe when used in oxidative hair colouring products up to a maximum on-head concentration of 2 %?

In light of the data provided, the SCCS considers that Hydroxypropyl p-Phenylenediamine and its dihydrochloride salt are not safe due to potential genotoxicity when used in oxidative hair colouring products up to a maximum on-head concentration of 2%.

2. Does the SCCS have any further scientific concerns with regard to the use of Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165) in cosmetic products?

A mild to moderate eye irritation potential of the test item cannot be excluded. Hydroxypropyl p-phenylenediamine 2HCl is a moderate skin sensitiser based on animal data.

For further information
• See the full text of SCCS (Scientific Committee on Consumer Safety), Opinion on 38 Hydroxypropyl p-phenylenediamine and its dihydrochloride salt (A165), SCCS/1608/19, preliminary 39 version adopted on 20-21 June 2019