CosmeticOBS - L'Observatoire des cosmétiques
March 11, 2019SCCS

Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87): Opinion of SCCS pro Add to my portfolio
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Methoxypropylamino cyclohexenylidene ethoxyethylcyanoacetate (S87): Opinion of CSSC

The SCCS has just published its second Opinion on the safety of the UV-filter Methoxypropylamino cyclohexenylidene ethoxyethylcyanoacetate (S87). It has been adopted during its plenary meeting of 26 February 2019 and is opened to comments until 13 May 2019.

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Background

In July 2017 the SCCS adopted an Opinion on Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) (CAS 1419401-88-9) (SCCS/1587/17), with the following conclusion:
“Based on the data provided, the SCCS is of the opinion that genotoxic potential of Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) cannot be excluded. Therefore, the SCCS cannot conclude on the safety of S87.
More evidence is needed to exclude the genotoxicity concern regarding S87.
On the basis of the studies provided, skin and eye irritation potential of the test item cannot be excluded. Dermal penetration data using 5% of the test material should also be provided.”

Submission II on the UV-filter Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) (CAS 1419401-88-9) was transmitted by Cosmetics Europe in July 2018.

For an exhaustive background information, see the article
Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87): Request for an Opinion to SCCS of September 17, 2018

Opinion

1. In light of the data provided, does the SCCS consider Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) safe when used as UV-filter in cosmetic products up to a maximum concentration of 3%?

Based on the data submitted, the SCCS concluded that the use of Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87), as a UV-filter in cosmetic products up to a maximum concentration of 3%, can be considered safe.
Inhalation toxicity was not assessed in ...