Monday, September 2, 2013Scientific publications

Anti-cavities toothpastes: arginine, as a fluorine enhancer


Released in the Journal of Dentistry August 2013 issue, this study of more than 400 Chinese volunteers, performed with Colgate-Palmolive, shows that a supply of 1.5% of arginine in a fluorinated (1450 ppm) toothpaste improves its anti-cavities efficiency in children. A new way for formulation?

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To compare the efficacy of a new dentifrice containing 1.5% arginine, an insoluble calcium compound and 1450 ppm fluoride to arrest and reverse naturally occurring buccal caries lesions in children relative to a positive control dentifrice containing 1450 ppm fluoride alone.

Study design

Participants from Chengdu, Sichuan Province, China tested three dentifrices: a new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride, as sodium monofluorophosphate, a positive control dentifrice containing 1450 ppm fluoride, as sodium fluoride, in a silica base, and a matched negative control dentifrice without arginine and fluoride. Quantitative Light-induced Fluorescence (QLF) was used to assess buccal caries lesions at baseline and after 3 and 6 months of product use.

Results: 438 participants (initial age 9–13 years (mean 11.1 ± 0.78) and 48.6% female) completed the study. No adverse events attributable to the products were reported during the course of the study. The subject mean Δ Q (mm² %), representing lesion volume, was 27.26 at baseline. After 6 months of product use, the Δ Q values for the arginine-containing, positive and negative control dentifrices were 13.46, 17.99 and 23.70 representing improvements from baseline of 50.6%, 34.0% and 13.1%. After 6 months product use, the differences between the pair wise comparisons for all three groups were statistically significant (p < 0.01). The arginine-containing dentifrice demonstrated an improvement after only 3 months that was almost identical to that achieved by the conventional 1450 ppm fluoride dentifrice after 6 months.


The new dentifrice containing 1.5% arginine, an insoluble calcium compound, and 1450 ppm fluoride provides statistically significantly superior efficacy in arresting and reversing buccal caries lesions to a conventional dentifrice containing 1450 ppm fluoride alone.

For further information
• Go to the full text of the article The anti-caries efficacy of a dentifrice containing 1.5% arginine and 1450 ppm fluoride as sodium monofluorophosphate assessed using Quantitative Light-induced Fluorescence (QLF) , published in the Journal of Dentistry, August 2013issue

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