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Thursday, July 9, 2015SCCS

Methylisothiazolinone does not pass the examination of SCCS

© CosmeticOBS-L'Observatoire des Cosmétiques

On June 25, 2015, during its 10th plenary meeting, the SCCS has adopted its Opinion on the cosmetic ingredient Methylisothiazolinone, as a preservative in rinse-off products and leave-on hair products. This Opinion is open for comments until September 8, 2015.

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Note: between the request for opinion to the SCCS and the publication of the latter, the background has been modified. Here is the whole new text.
• The first text of the Request for Opinion is available here .

The Scientific Committee on Cosmetic Products and Non-Food Products (SCCNFP) adopted two opinions on "Methylisothiazolinone" respectively in March 2003 (SCCNFP/0625/02) and in April 2004 (SCCNFP/0805/04).

The SCCNFP (March 2003 - SCCNFP/0625/02) concluded that the information submitted was insufficient at that time to allow an adequate risk assessment of Methylisothiazolinone to be carried out. The SCCNFP required: more detailed information concerning the physico-chemical properties of Methylisothiazolinone (e.g. LCMS analysis, pH, stability and degradation products); information on the material used in the tests (batch numbers, purity and impurities); an in vitro percutaneous absorption study and relevant and adequate genotoxicity/mutagenicity studies.

In response to the opinion of the SCCNFP concerning Methylisothiazolinone, adopted during the 23rd plenary meeting of 18 March 2003 (doc. n° SCCNFP/0625/02), additional information on the physico-chemical properties of the substance, an in vitro percutaneous absorption study and two studies on mutagenicity/genotoxicity were submitted to the SCCNFP for evaluation. In April 2004 the SCCNFP (SCCNFP/0805/04) concluded that the requested data were …

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