ex.VAT:
VAT:
inc.VAT:

Pharmacosmetech show 2022
Monday, January 17, 2022News

Genistein, Daidzein: preliminary Opinion of the SCCS

Genistein, Daidzein : Opinion préliminaire du CSSC

Following the mandate given by the European Commission to the SCCS in the context of the safety assessment of substances with potential endocrine disrupting properties, the Scientific Committee has just published its preliminary Opinion on Genistein and Daidzein. It was adopted by written procedure on 12 January 2022 and is open for comments until 14 March 2022.

Reading time
~ 3 minutes

Background

Phytoestrogens are plant-derived compounds with structural similarity to 17β-estradiol, the primary female sex hormone. Among the phenolic compounds classified as phytoestrogens are isoflavones.
Among the most common isoflavones are Genistein (CAS No.446-72-0, EC No.207-174-9) and Daidzein (CAS No.486-66-8, EC No.207-635-4).
Currently, Genistein and Daidzein are not regulated under the Cosmetic Regulation (EC) No.1223/2009.
During the call for data, stakeholders submitted scientific evidence to demonstrate the safety of Genistein and Daidzein in cosmetic products.

For an exhaustive background information, see the articles
Endocrine disruptors: 2nd call for data from the European Commission, CosmeticOBS, 22 February 2021
Endocrine disruptors: 5 new requests for SCCS Opinions, CosmeticOBS, 15 March 2021

Opinion

1. In light of the data provided and taking under consideration the concerns related to potential endocrine disrupting properties of phytoestrogens,
(a) does the SCCS consider Genistein safe when used in cosmetic products up to a maximum concentration of 0.007%?
(b) does the SCCS consider Daidzein safe when used in cosmetic products up to a maximum concentration of 0.02%?

From the safety assessment based on the available relevant data, and in consideration of the potential endocrine disrupting properties of phytoestrogens, the SCCS considers that:
a) The use …

This content is only available to subscribersPREMIUM, PRO, STARTUPandTPE

Already subscribed?Log in

Discover our subscriptions

Best ingredient innovation of 2022

NewsOther articles

1038results