Silab presents its latest cosmetic active ingredient, Lightskin, a natural depigmenting active ingredient obtained from biotechnological processes, rich in sulfur-containing peptides known for their capacity to limit melanogenesis.
Sulfur-containing peptides are molecules known for their transversal ability to limit melanogenesis. For its new depigmenting active ingredient, Silab has selected the yeast Ogataea siamensis, whose natural capacity to produce sulfur-containing molecules constitutes a considerable selective advantage for its development in the phyllosphere of the medicinal plant Ervatamia coronaria.
This potential was then enhanced by SILAB which decided to use its 15 years of expertise in biotechnologies to develop a unique process for bioguiding this yeast, specifically stimulating the production of large quantities of these molecules of interest.
A depigmenting action doubled
This richness in bioguided sulfur-containing peptides enabled the global depigmenting action of Lightskin to be doubled on Caucasian and Asian melanocytes, significantly limiting tyrosinase activity and melanin production.
This efficacy was also demonstrated in pro-pigmenting contexts of pollution (receptor related to pollution (AhR) inactivated) and glycation (expression of the receptor for AGEs inhibited).
This active ingredient was evaluated in volunteers selected on the presence of pigment spots, and more specifically on their high level of AGEs (Caucasian panel) or their history of living in polluted environments (Asian panel). The results showed that Lightskin at 2.5% reduces the appearance of spots after 56 days of treatment on both panels. …
