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Wednesday, March 23, 2011Publications

Skin diseases and allergies: a genetic factor involved?

©Georgi Georgiev/Thinkstock ? L?Observatoire des Cosmétiques

Since several years, it is known that genetic mutations of filaggrin (a protein involved in the skin barrier formation) may be the cause for skin diseases (atopic dermatitis, eczema) or have an influence on the seriousness of asthma-like lung diseases. A team of Scottish researchers has established a link between filaggrin and allergy to peanut. This allergy may come from food, but also via cosmetics application if they contain peanut derivatives (oil, powder, extract …).

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March 23, 2011
Filaggrin is a protein found in the epidermis keratinocytes. It helps for the organization of keratin filaments and the build-up of the epithelial cells envelop of the stratum corneum; it helps for the differentiation of the cells of the epidermis and the skin barrier formation.

In 2007, another team of researchers had already linked genetic mutations of this protein with an increased susceptibility to asthma-like disease and seriousness of symptoms on the one hand, and on the other hand with the skin disease incidence, among them: ichthyosis , eczema or atopic dermatitis .

Dr Sara Brown’s team, in the Dundee University (Scotland) has recently found a relevant correlation between genetic mutations of the filaggrin and allergy to peanut, in a paper published in The Journal of Allergy and Clinical Immunology , March 2011 Issue.

Twofold, even threefold risks

The prevalence of peanut allergy has increased dramatically over recent decades in developed countries. Even if genetic causes play a role in determining the risk of peanut allergy, the genes responsible have been largely unknown until now.

Scottish researchers have studied four population groups; in a Canadian population, the risk of peanut allergy was doubled in those with filaggrin …

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