Following the mandate given by the European Commission to the SCCS, in the framework of the evaluation of ingredients listed as endocrine disruptors, the Scientific Committee has just published its final Opinion on the safety of Triphenyl Phosphate. It has been adopted by written procedure on 25 July 2024.
Background
Triphenyl Phosphate (or TPP) (CAS No.204-112-2, EC No.115-86-6) is used to soften or make supple various synthetic polymers, including in nail polishes, enamels, or manicuring preparations.
It is not currently regulated under the Cosmetics Regulation (EC) No.1223/2009.
The substance was included in the European Commission’s second call for data on endocrine disruptors and was the subject of a mandate to the Scientific Committee on Consumer Safety. The SCCS published its preliminary Opinion in April 2024.
For an exhaustive background information, see the articles
• Endocrine disruptors: 2nd call for data from the European Commission, CosmeticOBS, 22 February 2021
• Benzophenone-4, Benzophenone-1, Triphenyl Phosphate: requests for Opinions to the SCCS, CosmeticOBS, 24 April 2023
• Triphenyl Phosphate: preliminary Opinion of the SCCS, CosmeticOBS, 8 April 2024
This Opinion has been subject to a commenting period of eight weeks after its initial publication (from 4 April to 2 June 2024). Comments received during this period were considered by the SCCS.
For this Opinion, main changes occurred in the following sections: SCCS comment page 11, SCCS comment on page 17, SCCS overall comment under 3.4.5.2, reference in Table 4, 3.4.9 human data, SCCS overall comment on ED activity, and …
