Half of worldwide population lives in cities and is daily exposed to urban pollution, consequently pollution has become a public health crisis. By 2030, urban population will reach 60% and up to 70% by 2050. The high levels of air pollutants are not limited to China or India anymore as western capitals like Paris and London often exceed the World Health Organization alert levels. Indeed, it is 90% of those citizens that are exposed to higher levels of air pollutant; particles PM10 & 2,5; than the World Health Organization limits⁽¹⁾. Nowadays a growing number of scientific and epidemiological studies have demonstrated that human exposure to environmental stress is associated with premature skin aging and hyper pigmentation⁽²⁾. The deleterious effect of those stress might be amplified with each other, when combined they form to the prooxidant smog also qualified as exposome⁽³⁾. The first epidemiological study was conducted on elderly Caucasian women, and showed that exposure to traffic related Particles Matter (PM2.5-PM10) contributes to skin aging⁽²⁾. More studies were performed to provide further evidence for that pollution can accelerate skin aging^(4,5,6). Not only wrinkle formation but also pigmentation spots appearance could be …