Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87): Request for an Opinion to SCCS

The safety of the UV-filter Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) will be re-assessed by the SCCS. The request from the European Commission was published on September, 2018. The Scientific Committee has until February 2019 to give its Opinion.

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Background

Submission I on the UV-filter Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) (CAS 1419401-88-9), with the chemical name 2-Ethoxyethyl (2Z)-2-cyano-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetate, was submitted by Cosmetics Europe in June 2016.
In July 2017 the SCCS adopted an Opinion on Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) (CAS 1419401-88-9) (SCCS/1587/17), with the following conclusion:
“Based on the data provided, the SCCS is of the opinion that genotoxic potential of Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) cannot be excluded. Therefore, the SCCS cannot conclude on the safety of S87.
More evidence is needed to exclude the genotoxicity concern regarding S87.
On the basis of the studies provided, skin and eye irritation potential of the test item cannot be excluded. Dermal penetration data using 5% of the test material should also be provided.”

Submission II on the UV-filter Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) (CAS 1419401-88-9) was transmitted by Cosmetics Europe in July 2018.
According to the applicant the current submission constitutes industry’s response to the request for further information in the first SCCS Opinion (SCCS/1587/17). In addition the current submission is intended to support the use of Methoxypropylamino Cyclohexenylidene Ethoxyethylcyanoacetate (S87) as UV-filter in cosmetic products up to a maximum concentration of 3%.